March 7, 2013

How pharma firms jack your bills up through payoffs to would-be competitors

Since most people get most of their medicine at least subsidized by health insurance or Medicare/Medicaid, there isn't much general interest in the murky deals made by pharmaceutical firms with potential competitors, generic manufacturers, to hold on to monopoly profits a little longer. But an upcoming Supreme Court case will shine a light on this.

A reader explains:
It's all controlled by the Hatch-Waxman Act; the Wikipedia article is better than the average one on a controversial subject, though out of date. But even when a patent expires, the generic doesn't get to sell until they get FDA approval that they're manufacturing the generic to a +/-20% approximation of the original drug. I've had pharma execs complain bitterly to me that the generics aren't the same thing. 

Ranbaxy of India had a two year right to be the only generic manufacturer of gigadrug Lipitor, but agreed with Pfizer to delay introducing a generic version. Then when they did introduce a generic, it had to be recalled for having glass particles in the pills!
Wrt to generics cutting sweetheart deals with patent holders ("pay for delay"), the FTC has been complaining about it for years, but pharma kept beating it back in court -- until last year, and now the Supreme Court is stepping in to resolve the question once and for all, or at least until lobbyists on one side or the other get to Congress. It's getting argued in three weeks, so you'll start to see a lot of news stories about the issue soon.   

Here's the summary of the upcoming case involving Andrew Sullivan's favorite career pick-me-up AndroGel:
FTC v. Actavis (formerly Watson): 
Issue: Whether reverse-payment agreements are per se lawful unless the underlying patent litigation was a sham or the patent was obtained by fraud (as the court below held), or instead are presumptively anticompetitive and unlawful (as the Third Circuit has held). (Alito, J., recused)

The Foley law firm explains:
ANDA litigation often is settled by a "reverse payment" agreement, wherein the patent owner pays the would-be generic company (the ANDA filer) to stay off the market for a period of time. (It is called a "reverse" payment because usually it is the infringer who pays the patent owner.) 

In other words, the firm with the original patent pays the challenger to take a dive in the lawsuit.
While patents are given special treatment under antitrust laws, the FTC does not like reverse payment settlement agreements. According to the FTC's assertions in its petition for certiorari in the Watson AndroGel® case: 
Reverse-payment agreements tend to support monopoly pricing of brand-name drugs by delaying the onset of generic competition .... 
Reverse-payment agreements ... [cost] consumers billions of dollars each year. 
The FTC also implies that the majority of patents would be invalidated if litigation proceeded: 
[A] substantial fraction of fully litigated patent cases have, historically, resulted in a finding of patent invalidity. 
Overall, in cases litigated to decision, would-be generic competitors have prevailed three quarters of the time in paragraph IV patent litigation against brand-name manufacturers.

This sounds boring, but giant piles of money are involved.

10 comments:

wren said...

I have read, but not checked, that big pharma was responsible for writing much of obamacare.

If this is true, we can expect much less access to generics in the future.

Karl said...

Have you considered that Sullivan started on T for legitimate medical reasons relating to his HIV status?

Common realities of HIV+ life, some things shrink, ya know. Jus sayin.

Karl

Anonymous said...

How can a company have exclusive rights to be the manufacturer of a "generic" drug? Isn't that a paradox?
--Ollie

Anonymous said...

How can a company have exclusive rights to manufacture a supposedly "generic" dug? Isn't this a contradiction in terms?

Anonymous said...

Ranbaxy of India had a two year right to be the only generic manufacturer of gigadrug Lipitor, but agreed with Pfizer to delay introducing a generic version. Then when they did introduce a generic, it had to be recalled for having glass particles in the pills!

So the manufacture of pharmaceuticals constitutes yet another category of jobs which Americans just won't do anymore?

Too much physical labor?

Too low-tech?

Too passe?

Too demeaning?


PS: Mahindra has started advertising on the Rush Limbaugh show - at least out here in flyover country.

Cue John Deere rolling over in his grave...

DPG said...

My girlfriend's roommate works in BigLaw, often representing Big Pharma. For one case, the firm was trying to get an injunction against a generic drug. It was so profitable that if they succeeded in delaying the entry of the generic drug into the market for even one day, it would pay for all of the legal fees.

Anonymous said...

So we can save the budget by just letting entitlements go generic?

Anonymous said...

How is this practice, at its root, not a form of "price fixing"?

-Cloudswrest

Anonymous said...

I'd like to see proof of payoffs made by Big Pharma to the Religious Right. "Nuke the potheads for Generalissimo Jesus" bumper stickers, and the like?

David said...

>jobs which Americans just won't do anymore?

Too much physical labor?

Too low-tech?

Too passe?

Too demeaning?<

You omitted to mention "too low-pay."

Eight bucks per hour would just cover my gas plus a micro bag of chips. If that's all the available "jobs" pay, then it makes more sense to stay home and cook meth and/or chop cars.